Even the celebs are finally speaking out: beauty is just not worth testing Botox on animals. Botox, or botulinum toxin, is a treatment commonly used to eliminate the appearance of wrinkles. Before a single batch of the anti-wrinkle injection can reach consumers, however, it is reportedly tested upon mice.

But what has become a popular cosmetic procedure originally endorsed by celebrities is now earning a bad wrap from beauty icons like Joss Stone, Joanna Lumley, Ricky Gervais and Lucy Davis.

“Please, don’t allow animals, who feel pain and fear just like we do, to suffer simply for our own vanity,”  the U.K.’s “The Office’s” Davis pleaded.

Stone echoed her sentiments:

“We can stop this cruel and unnecessary act by bringing light to what has clearly been done in darkness for too long,” Stone said. “I think it is a sick way to test something that is for cosmetic use. They are not trying to cure cancer here; this is about smoothing the wrinkles on the faces of women and men. How many innocent animals have to suffer? Let’s put a stop to this cruel, inhumane, and above all unnecessary act.”

Reports identifying the realities behind the production of Botox have only recently become public knowledge. A British Union for the Abolition of Vivisection (BUAV) investigation uncovered the evidence that “Lethal Dose 50″ (LD50) poisoning tests are used on mice and that mice do endure discomfort, even pain, from the injections.

“Mice suffer increasing paralysis and difficulty breathing and will, if left unattended, eventually suffocate to death,” Look to the Stars reported.

Celebrities are beginning to rally behind the BUAV study which urges Botox manufacturers such as Ipsen, Allergan and Merz-Pharma to put an end to their animal cruelty.

“I hate the idea that people wanting to be beautiful and smooth should use such an ugly and cruel product,” said Joanna Lumley. “Don’t touch it: support instead the brilliant substitute for animal testing, and keep your conscience as unmarked as your brow.”

Studies show that there are alternatives to using live animals in Botox testing. SNAP-25 is a procedure that measures the activity of the toxin in test tubes and can be used in place of the LD50 test.

Sign this petition to help end animal testing now.